266 papers
This study reveals that the Drosophila ovarian terminal filament acts as a critical gateway for importing lipophilic molecules like ecdysone via organic anion transporters and vesicular transcytosis to regulate local follicle development within the ovariole.
This study establishes that androgen receptor signaling is essential for maintaining skeletal muscle stem cell quiescence and reservoir integrity, as its loss leads to premature activation and stem cell depletion, while androgen supplementation can restore regenerative capacity.
This study demonstrates that the Hox transcription factor MAB-5 drives posterior Q neuroblast migration in *C. elegans* by regulating EFN-4/Ephrin, which converges with SAX-3/Robo, UNC-6/Netrin, and heparan sulfate proteoglycan signaling to form a large extracellular complex essential for the final stage of cell movement.
This study demonstrates that the disease-associated microRNA miR-9-2, regulated by a conserved enhancer, is essential for controlling the timing of retinal progenitor cell competence and maintaining Müller glial identity through the regulation of specific transcription factors and a negative feedback loop.
This study reveals that the metabolic maturation of human motoneurons from hiPSCs is not a simple, monotonic switch from glycolysis to oxidative phosphorylation, but rather a complex, nonlinear process characterized by intermittent glycolytic peaks during intermediate stages and a definitive oxidative shift only upon final differentiation.
This study demonstrates that *MYBPC3* mutations drive hypertrophic cardiomyopathy by disrupting early postnatal ventricular wall patterning and maturation through impaired cardiomyocyte proliferation and *Prdm16* downregulation, establishing a developmental origin for the disease and identifying postnatal *Prdm16* restoration as a potential therapeutic strategy.
This study establishes extruded *C. elegans* gonads as a viable tissue explant system that retains key developmental processes and drug responsiveness, thereby enabling the combination of live-cell imaging and acute drug treatment to investigate germline development mechanisms.
This study demonstrates that canonical mTOR signaling, rather than the salamander-specific hypersensitive variant, is sufficient to drive complete fin regeneration in the Senegal bichir by regulating translational machinery, glycolytic programs, and pro-regenerative myeloid cell responses.
This study reveals that the Gcn5-mTORC1-TFEB signaling axis regulates autophagy to maintain blood cell homeostasis in the Drosophila lymph gland, where Gcn5 acts as a nutrient sensor controlling TFEB-mediated autophagic flux, a process that is ultimately overridden by mTORC1 activity.
This study demonstrates that the gain of chromosome 20q11.21 in human pluripotent stem cells confers a persistent competitive advantage while disrupting neural and retinal lineage specification through the synergistic action of the dosage-sensitive genes BCL2L1 and ID1, which redirect cells toward non-neural and extraembryonic fates.
This study utilizes single-cell transcriptomic profiling of approximately 130,000 cells from postnatal day 2 to day 60 to provide the first high-resolution molecular map of anterior segment development, specifically elucidating the cell types, signaling pathways, and dynamic interactions that drive the formation of the trabecular meshwork and Schlemm's canal to advance the understanding of glaucoma and ocular physiology.
This study reveals that subtle pre-existing morphological differences, specifically in apical cell area and contact dynamics, bias cells toward signal-sending or receiving roles in Notch-mediated lateral inhibition, with subsequent mechanical feedback reinforcing these roles to ensure robust neuroblast selection.
This study investigates the retinal development of the cone-less little skate, revealing a novel, embryonically enriched Onecut1 splice isoform (LSOC1X2) that retains regulatory activity and may play a key role in the unique photoreceptor development of elasmobranchs.
This study establishes a rapid in vitro platform that combines microinjection of genetic materials into mouse secondary follicles with a two-step culture system, enabling efficient functional analysis of maternal effect genes during oocyte growth while preserving developmental competence.
This study demonstrates that placental pericytes are progressively recruited with phenotypic diversity during gestation and reveals that soluble PDGFRβ isoforms, which are upregulated under hypoxia, modulate PDGF-BB signaling to potentially regulate fetoplacental vascular maturation.
This study presents the design and experimental validation of 25 novel CRISPR/Cas9 guide RNAs targeting eight key neurodevelopmental genes in the tunicate *Ciona robusta*, demonstrating high mutagenesis efficacy and evaluating the predictive accuracy of Doench scoring algorithms for future guide selection.
This study constructs the first single-cell transcriptomic atlas of the adult *Spodoptera litura* ovary, integrating cross-species comparisons, spatial validation, and functional RNAi assays to define cellular populations, regulatory networks, and potential targets for pest control.
This study identifies a Wnt-responsive fibrocartilage progenitor system in the postnatal mandibular condyle that coordinates growth by utilizing Foxm1 to maintain proliferation while suppressing TGF-β-driven chondrogenic differentiation to ensure proper tissue organization.
This study demonstrates that analyzing mitochondrial subpopulations at single-organelle resolution, rather than relying on aggregate measurements, reveals distinct age-associated alterations in oocytes and cumulus cells that are otherwise undetectable, while also showing that NMN supplementation induces specific, subpopulation-dependent rejuvenation effects in these cells.
This study demonstrates that the transcriptional upregulation of both nuclear-encoded and mitochondrially transcribed genes occurs during early human pre-implantation embryogenesis prior to oxidative phosphorylation activation and lineage specification, suggesting mitochondria actively contribute to early developmental programming through mechanisms beyond energy production.